| 16. Round | 12/02/2022 | US Alessandria 1912 [Youth] | - | US Cremonese [Youth] | 1:4 | ||||
| 17. Round | 19/02/2022 | Brescia Calcio [Youth] | - | US Alessandria 1912 [Youth] | 3:2 |  |
|||
| 18. Round | 26/02/2022 | US Alessandria 1912 [Youth] | - | L.R. Vicenza [Youth] | 0:1 | ||||
| 20. Round | 12/03/2022 | US Alessandria 1912 [Youth] | - | AS Cittadella [Youth] | 3:3 | ||||
| 21. Round | 19/03/2022 | Venezia FC [Youth] | - | US Alessandria 1912 [Youth] | 5:1 |  |
|||
| 22. Round | 26/03/2022 | US Alessandria 1912 [Youth] | - | AC Monza [Youth] | 2:3 | |
|||
| 23. Round | 02/04/2022 | Virtus Entella [Youth] | - | US Alessandria 1912 [Youth] | 0:0 | ||||
| 24. Round | 09/04/2022 | US Alessandria 1912 [Youth] | - | AC Reggiana 1919 [Youth] | 4:0 | ||||
| 25. Round | 15/04/2022 | Udinese Calcio [Youth] | - | US Alessandria 1912 [Youth] | 8:1 | |
Italy