| 1. Round | 28/08/2010 | Levante UD | - | Sevilla FC | 1:4 |  |
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| 3. Round | 19/09/2010 | Málaga CF | - | Sevilla FC | 1:2 | |
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| 4. Round | 23/09/2010 | Sevilla FC | - | Racing Santander | 1:1 | ||||
| 12. Round | 21/11/2010 | Sevilla FC | - | RCD Mallorca | 1:2 | ||||
| 14. Round | 05/12/2010 | Villarreal CF | - | Sevilla FC | 1:0 | ||||
| 18. Round | 08/01/2011 | Real Sociedad | - | Sevilla FC | 2:3 |
Italy