| 1. Round | 11/09/2021 | Parma Calcio 1913 [Youth] | - | US Alessandria 1912 [Youth] | 6:1 | ||||
| 9. Round | 20/11/2021 | AC Monza [Youth] | - | US Alessandria 1912 [Youth] | 1:1 | ||||
| 11. Round | 04/12/2021 | AC Reggiana 1919 [Youth] | - | US Alessandria 1912 [Youth] | 0:1 | ||||
| 12. Round | 14/12/2021 | US Alessandria 1912 [Youth] | - | Udinese Calcio [Youth] | 2:0 | ||||
| 14. Round | 29/01/2022 | US Alessandria 1912 [Youth] | - | Parma Calcio 1913 [Youth] | 1:4 | ||||
| 15. Round | 05/02/2022 | Pordenone Calcio [Youth] | - | US Alessandria 1912 [Youth] | 0:2 |  |
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| 16. Round | 12/02/2022 | US Alessandria 1912 [Youth] | - | US Cremonese [Youth] | 1:4 | ||||
| 17. Round | 19/02/2022 | Brescia Calcio [Youth] | - | US Alessandria 1912 [Youth] | 3:2 |  |
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| 19. Round | 07/03/2022 | Como 1907 [Youth] | - | US Alessandria 1912 [Youth] | 4:4 | |
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| 22. Round | 26/03/2022 | US Alessandria 1912 [Youth] | - | AC Monza [Youth] | 2:3 | ||||
| 24. Round | 09/04/2022 | US Alessandria 1912 [Youth] | - | AC Reggiana 1919 [Youth] | 4:0 | ||||
| 25. Round | 15/04/2022 | Udinese Calcio [Youth] | - | US Alessandria 1912 [Youth] | 8:1 |
Italy