| 5. Round | 23/10/1960 | SPAL Ferrara | - | Sampdoria | 2:2 | ||||
| 6. Round | 06/11/1960 | Sampdoria | - | Lazio Roma | 1:0 | ||||
| 10. Round | 04/12/1960 | Sampdoria | - | Atalanta | 1:0 | ||||
| 11. Round | 18/12/1960 | Calcio Catania | - | Sampdoria | 3:0 | ||||
| 12. Round | 25/12/1960 | Juventus | - | Sampdoria | 3:2 | ||||
| 15. Round | 15/01/1961 | Sampdoria | - | AS Bari | 1:0 |  |
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| 17. Round | 29/01/1961 | Sampdoria | - | Bologna FC | 2:1 | ||||
| 18. Round | 05/02/1961 | Sampdoria | - | Torino FC | 2:1 | ||||
| 22. Round | 05/03/1961 | Sampdoria | - | SPAL Ferrara | 1:1 | ||||
| 23. Round | 12/03/1961 | Lazio Roma | - | Sampdoria | 0:1 | ||||
| 24. Round | 19/03/1961 | Sampdoria | - | Calcio Lecco 1912 | 1:0 | ||||
| 26. Round | 02/04/1961 | Sampdoria | - | Inter | 4:2 | ||||
| 27. Round | 09/04/1961 | Atalanta | - | Sampdoria | 0:3 | ||||
| 28. Round | 16/04/1961 | Sampdoria | - | Calcio Catania | 2:0 | ||||
| 29. Round | 30/04/1961 | Sampdoria | - | Juventus | 3:2 | ||||
| 30. Round | 07/05/1961 | Calcio Padova | - | Sampdoria | 3:0 | ||||
| 31. Round | 14/05/1961 | Sampdoria | - | AS Roma | 3:2 | ||||
| 32. Round | 21/05/1961 | AS Bari | - | Sampdoria | 1:0 | ||||
| 33. Round | 30/05/1961 | Sampdoria | - | Udinese Calcio | 3:2 | ||||
| 34. Round | 04/06/1961 | Bologna FC | - | Sampdoria | 4:4 |
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