| 1. Round | 16/08/2021 | Blackburn Rovers U23 | - | Everton FC U23 | 2:2 | ||||
| 2. Round | 23/08/2021 | Everton FC U23 | - | Liverpool FC U23 | 1:3 | ||||
| 3. Round | 27/08/2021 | Crystal Palace U23 | - | Everton FC U23 | 3:1 | ||||
| 4. Round | 10/09/2021 | Everton FC U23 | - | Derby County U23 | 1:0 | ||||
| 5. Round | 20/09/2021 | Leicester City U23 | - | Everton FC U23 | 3:1 | ||||
| 6. Round | 24/09/2021 | Everton FC U23 | - | Manchester United U23 | 0:1 | ||||
| 7. Round | 02/10/2021 | West Ham United U23 | - | Everton FC U23 | 3:1 | ||||
| 8. Round | 18/10/2021 | Everton FC U23 | - | Leeds United U23 | 4:2 |  |
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| 9. Round | 22/10/2021 | Arsenal FC U23 | - | Everton FC U23 | 4:0 | ||||
| 20. Round | 21/02/2022 | Derby County U23 | - | Everton FC U23 | 0:2 | ||||
| 22. Round | 11/03/2022 | Brighton & Hove Albion U23 | - | Everton FC U23 | 4:2 | |
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| 23. Round | 18/03/2022 | Manchester United U23 | - | Everton FC U23 | 3:0 | ||||
| 24. Round | 04/04/2022 | Everton FC U23 | - | Blackburn Rovers U23 | 0:2 | ||||
| 21. Round | 15/04/2022 | Everton FC U23 | - | Chelsea FC U23 | 2:0 | ||||
| 25. Round | 25/04/2022 | Everton FC U23 | - | West Ham United U23 | 3:4 |  |
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| 26. Round | 29/04/2022 | Manchester City U23 | - | Everton FC U23 | 7:0 |
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