| 15. Round | 25/11/2000 | Derby County | - | Manchester United | 0:3 | ||||
| 17. Round | 09/12/2000 | Charlton Athletic | - | Manchester United | 3:3 | ||||
| 18. Round | 17/12/2000 | Manchester United | - | Liverpool FC | 0:1 |  |
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| 21. Round | 30/12/2000 | Newcastle United | - | Manchester United | 1:1 | ||||
| 23. Round | 13/01/2001 | Bradford City | - | Manchester United | 0:3 |  |
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| 24. Round | 20/01/2001 | Manchester United | - | Aston Villa | 2:0 | ||||
| 26. Round | 03/02/2001 | Manchester United | - | Everton FC | 1:0 | ||||
| 28. Round | 25/02/2001 | Manchester United | - | Arsenal FC | 6:1 | ||||
| 29. Round | 03/03/2001 | Leeds United | - | Manchester United | 1:1 | |
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| 30. Round | 17/03/2001 | Manchester United | - | Leicester City | 2:0 | ||||
| 31. Round | 31/03/2001 | Liverpool FC | - | Manchester United | 2:0 | ||||
| 35. Round | 21/04/2001 | Manchester United | - | Manchester City | 1:1 | ||||
| 36. Round | 28/04/2001 | Middlesbrough FC | - | Manchester United | 0:2 | ||||
| 37. Round | 05/05/2001 | Manchester United | - | Derby County | 0:1 | ||||
| 34. Round | 13/05/2001 | Southampton FC | - | Manchester United | 2:1 |
England