| 1. Round | 14/08/2021 | VfB Stuttgart | - | SpVgg Greuther Fürth | 5:1 |  |
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| 2. Round | 20/08/2021 | RB Leipzig | - | VfB Stuttgart | 4:0 |  |
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| 3. Round | 28/08/2021 | VfB Stuttgart | - | SC Freiburg | 2:3 | ||||
| 4. Round | 12/09/2021 | Eintracht Frankfurt | - | VfB Stuttgart | 1:1 | ||||
| 5. Round | 19/09/2021 | VfB Stuttgart | - | Bayer Leverkusen | 1:3 | ||||
| 6. Round | 26/09/2021 | VfL Bochum | - | VfB Stuttgart | 0:0 | ||||
| 7. Round | 02/10/2021 | VfB Stuttgart | - | 1899 Hoffenheim | 3:1 | |
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| 8. Round | 16/10/2021 | Bor. Mönchengladbach | - | VfB Stuttgart | 1:1 | |
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| 9. Round | 24/10/2021 | VfB Stuttgart | - | 1. FC Union Berlin | 1:1 | ||||
| 10. Round | 31/10/2021 | FC Augsburg | - | VfB Stuttgart | 4:1 | ||||
| 15. Round | 11/12/2021 | VfL Wolfsburg | - | VfB Stuttgart | 0:2 | ||||
| 16. Round | 14/12/2021 | VfB Stuttgart | - | Bayern München | 0:5 |
Germany
