| 1. Round | 25/07/2021 | Śląsk Wrocław | - | Warta Poznań | 2:2 | ||||
| 3. Round | 08/08/2021 | Śląsk Wrocław | - | Lechia Gdańsk | 1:1 | ||||
| 4. Round | 15/08/2021 | Śląsk Wrocław | - | Górnik Łęczna | 0:0 | ||||
| 5. Round | 22/08/2021 | Piast Gliwice | - | Śląsk Wrocław | 1:1 | ||||
| 6. Round | 29/08/2021 | Zagłębie Lubin | - | Śląsk Wrocław | 1:3 |  |
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| 7. Round | 11/09/2021 | Śląsk Wrocław | - | Legia Warszawa | 1:0 | ||||
| 8. Round | 18/09/2021 | Radomiak Radom | - | Śląsk Wrocław | 1:1 | ||||
| 9. Round | 26/09/2021 | Śląsk Wrocław | - | Wisła Płock | 3:1 | |
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| 10. Round | 02/10/2021 | Lech Poznań | - | Śląsk Wrocław | 4:0 | ||||
| 11. Round | 16/10/2021 | Śląsk Wrocław | - | Raków Częstochowa | 1:2 | |
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| 12. Round | 23/10/2021 | Wisła Kraków | - | Śląsk Wrocław | 0:5 | ||||
| 13. Round | 30/10/2021 | Bruk-Bet Termalica Nieciecza | - | Śląsk Wrocław | 4:3 | ||||
| 14. Round | 05/11/2021 | Śląsk Wrocław | - | Jagiellonia Białystok | 2:2 | ||||
| 16. Round | 27/11/2021 | Śląsk Wrocław | - | FKS Stal Mielec | 2:1 | |
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| 17. Round | 03/12/2021 | Górnik Zabrze | - | Śląsk Wrocław | 3:1 |
Poland