| 2. Round | 18/09/2021 | US Alessandria 1912 [Youth] | - | Pordenone Calcio [Youth] | 0:4 | ||||
| 4. Round | 02/10/2021 | US Alessandria 1912 [Youth] | - | Brescia Calcio [Youth] | 1:2 |  |
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| 8. Round | 06/11/2021 | US Alessandria 1912 [Youth] | - | Venezia FC [Youth] | 1:1 | ||||
| 10. Round | 27/11/2021 | US Alessandria 1912 [Youth] | - | Virtus Entella [Youth] | 1:3 | ||||
| 11. Round | 04/12/2021 | AC Reggiana 1919 [Youth] | - | US Alessandria 1912 [Youth] | 0:1 | ||||
| 12. Round | 14/12/2021 | US Alessandria 1912 [Youth] | - | Udinese Calcio [Youth] | 2:0 | ||||
| 19. Round | 07/03/2022 | Como 1907 [Youth] | - | US Alessandria 1912 [Youth] | 4:4 | ||||
| 23. Round | 02/04/2022 | Virtus Entella [Youth] | - | US Alessandria 1912 [Youth] | 0:0 | ||||
| 24. Round | 09/04/2022 | US Alessandria 1912 [Youth] | - | AC Reggiana 1919 [Youth] | 4:0 | |
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| 25. Round | 15/04/2022 | Udinese Calcio [Youth] | - | US Alessandria 1912 [Youth] | 8:1 |
Italy