| 18. Round | 24/01/2022 | Everton FC U23 | - | Tottenham Hotspur U23 | 1:0 | ||||
| 19. Round | 07/02/2022 | Tottenham Hotspur U23 | - | Crystal Palace U23 | 1:4 | ||||
| 21. Round | 28/02/2022 | Tottenham Hotspur U23 | - | Leeds United U23 | 1:1 | ||||
| 15. Round | 04/03/2022 | Arsenal FC U23 | - | Tottenham Hotspur U23 | 2:1 | ||||
| 22. Round | 12/03/2022 | Liverpool FC U23 | - | Tottenham Hotspur U23 | 7:1 | ||||
| 24. Round | 04/04/2022 | West Ham United U23 | - | Tottenham Hotspur U23 | 3:1 |  |
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| 25. Round | 25/04/2022 | Derby County U23 | - | Tottenham Hotspur U23 | 0:1 |  |
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| 26. Round | 02/05/2022 | Tottenham Hotspur U23 | - | Brighton & Hove Albion U23 | 0:0 | ||||
| 20. Round | 08/05/2022 | Chelsea FC U23 | - | Tottenham Hotspur U23 | 2:1 | |
England