| Group A | 16/09/2021 | Rangers FC | - | Olympique Lyonnais | 0:2 | ||||
| Group A | 30/09/2021 | Olympique Lyonnais | - | Brøndby IF | 3:0 |  |
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| Group A | 21/10/2021 | AC Sparta Praha | - | Olympique Lyonnais | 3:4 | ||||
| Group A | 04/11/2021 | Olympique Lyonnais | - | AC Sparta Praha | 3:0 | ||||
| Group A | 25/11/2021 | Brøndby IF | - | Olympique Lyonnais | 1:3 | ||||
| Group A | 09/12/2021 | Olympique Lyonnais | - | Rangers FC | 1:1 | ||||
| Round of 16 | 09/03/2022 | FC Porto | - | Olympique Lyonnais | 0:1 | ||||
| Round of 16 | 17/03/2022 | Olympique Lyonnais | - | FC Porto | 1:1 | |
France