| 2. Round | 14/08/2021 | Burton Albion | - | Ipswich Town | 2:1 | ||||
| 3. Round | 17/08/2021 | Burton Albion | - | Sunderland AFC | 1:0 | ||||
| 6. Round | 06/09/2021 | Bolton Wanderers | - | Burton Albion | 0:0 | ||||
| 7. Round | 11/09/2021 | Burton Albion | - | Gillingham FC | 1:1 | ||||
| 8. Round | 18/09/2021 | Crewe Alexandra | - | Burton Albion | 2:0 | ||||
| 9. Round | 25/09/2021 | Burton Albion | - | Lincoln City | 1:2 |  |
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| 10. Round | 28/09/2021 | Burton Albion | - | Portsmouth FC | 2:1 | ||||
| 15. Round | 23/10/2021 | Burton Albion | - | Oxford United | 1:3 | |
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| 16. Round | 30/10/2021 | Wigan Athletic | - | Burton Albion | 2:0 | ||||
| 18. Round | 20/11/2021 | Milton Keynes Dons | - | Burton Albion | 1:0 |
England
