| 18. Round | 10/01/2021 | Ternana Calcio | - | SS Monopoli 1966 | 2:1 | ||||
| 19. Round | 17/01/2021 | SS Monopoli 1966 | - | US Catanzaro | 1:1 | ||||
| 21. Round | 31/01/2021 | Calcio Catania | - | SS Monopoli 1966 | 3:1 | ||||
| 35. Round | 11/04/2021 | SS Monopoli 1966 | - | Paganese Calcio | 3:1 |  |
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| 33. Round | 15/04/2021 | SS Monopoli 1966 | - | Casertana FC | 0:1 |
Italy