| 2. Round | 20/09/1980 | AS Roma | - | Brescia Calcio | 1:0 | ||||
| 3. Round | 27/09/1980 | Bologna FC | - | AS Roma | 1:1 | ||||
| 5. Round | 19/10/1980 | SSC Napoli | - | AS Roma | 4:0 | ||||
| 6. Round | 26/10/1980 | Inter | - | AS Roma | 2:4 | ||||
| 11. Round | 20/12/1980 | AS Roma | - | Ascoli Calcio | 4:1 | ||||
| 16. Round | 07/02/1981 | AS Roma | - | Como Calcio | 1:1 | ||||
| 19. Round | 28/02/1981 | Torino FC | - | AS Roma | 0:2 | ||||
| 20. Round | 07/03/1981 | AS Roma | - | SSC Napoli | 1:1 | ||||
| 21. Round | 14/03/1981 | AS Roma | - | Inter | 1:0 | ||||
| 22. Round | 21/03/1981 | US Catanzaro | - | AS Roma | 1:1 | ||||
| 24. Round | 04/04/1981 | Udinese Calcio | - | AS Roma | 0:2 | ||||
| 29. Round | 16/05/1981 | AS Roma | - | AC Pistoiese | 1:0 |
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