| 4. Round | 29/09/1957 | Hellas Verona | - | US Alessandria 1912 | 3:0 | ||||
| 8. Round | 27/10/1957 | US Alessandria 1912 | - | Bologna FC | 2:0 |  |
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| 9. Round | 04/11/1957 | Genoa CFC | - | US Alessandria 1912 | 0:2 | ||||
| 10. Round | 10/11/1957 | US Alessandria 1912 | - | SSC Napoli | 0:0 | ||||
| 11. Round | 17/11/1957 | US Alessandria 1912 | - | AC Lanerossi Vicenza | 2:1 | ||||
| 13. Round | 08/12/1957 | US Alessandria 1912 | - | Sampdoria | 2:0 | ||||
| 15. Round | 29/12/1957 | Atalanta | - | US Alessandria 1912 | 1:1 | |
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| 16. Round | 05/01/1958 | US Alessandria 1912 | - | Juventus | 1:2 | ||||
| 17. Round | 19/01/1958 | Udinese Calcio | - | US Alessandria 1912 | 2:0 | ||||
| 20. Round | 09/02/1958 | AC Milan | - | US Alessandria 1912 | 1:1 | ||||
| 21. Round | 16/02/1958 | US Alessandria 1912 | - | Hellas Verona | 3:1 | ||||
| 22. Round | 23/02/1958 | Lazio Roma | - | US Alessandria 1912 | 2:1 | |
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| 23. Round | 02/03/1958 | US Alessandria 1912 | - | Inter | 2:1 | ||||
| 24. Round | 09/03/1958 | US Alessandria 1912 | - | SPAL Ferrara | 0:0 | ||||
| 27. Round | 06/04/1958 | SSC Napoli | - | US Alessandria 1912 | 4:1 | ||||
| 34. Round | 25/05/1958 | US Alessandria 1912 | - | Udinese Calcio | 1:2 |
Italy