| 2. Round | 11/09/2021 | SSC Napoli [Youth] | - | Sampdoria [Youth] | 1:6 | ||||
| 4. Round | 27/09/2021 | SSC Napoli [Youth] | - | Delfino Pescara [Youth] | 1:3 |  |
|||
| 7. Round | 31/10/2021 | Empoli FC [Youth] | - | SSC Napoli [Youth] | 1:0 | ||||
| 9. Round | 21/11/2021 | Torino FC [Youth] | - | SSC Napoli [Youth] | 1:2 | ||||
| 10. Round | 26/11/2021 | SSC Napoli [Youth] | - | US Lecce [Youth] | 1:0 | |
|||
| 12. Round | 11/12/2021 | Cagliari Calcio [Youth] | - | SSC Napoli [Youth] | 3:0 | ||||
| 15. Round | 29/01/2022 | Genoa CFC [Youth] | - | SSC Napoli [Youth] | 1:2 | ||||
| 16. Round | 02/02/2022 | SSC Napoli [Youth] | - | SPAL 2013 Ferrara [Youth] | 4:2 | ||||
| 17. Round | 06/02/2022 | Hellas Verona [Youth] | - | SSC Napoli [Youth] | 2:1 | ||||
| 18. Round | 13/02/2022 | SSC Napoli [Youth] | - | Bologna FC [Youth] | 1:2 | ||||
| 19. Round | 16/02/2022 | Sampdoria [Youth] | - | SSC Napoli [Youth] | 2:1 | ||||
| 20. Round | 19/02/2022 | SSC Napoli [Youth] | - | Juventus [Youth] | 0:5 | ||||
| 14. Round | 02/03/2022 | ACF Fiorentina [Youth] | - | SSC Napoli [Youth] | 1:0 | ||||
| 23. Round | 09/03/2022 | Atalanta [Youth] | - | SSC Napoli [Youth] | 1:0 |
Senegal