| 19. Round | 30/01/2022 | SD Eibar [Women] | - | Madrid CFF [Women] | 2:1 | ||||
| 20. Round | 02/02/2022 | Athletic Club [Women] | - | SD Eibar [Women] | 3:1 | ||||
| 21. Round | 06/02/2022 | FC Barcelona [Women] | - | SD Eibar [Women] | 7:0 | ||||
| 22. Round | 13/02/2022 | SD Eibar [Women] | - | Real Madrid [Women] | 0:2 | ||||
| 23. Round | 06/03/2022 | Real Sociedad [Women] | - | SD Eibar [Women] | 2:1 |  |
|||
| 24. Round | 12/03/2022 | SD Eibar [Women] | - | Sporting de Huelva [Women] | 1:2 | |
|||
| 26. Round | 03/04/2022 | SD Eibar [Women] | - | CD Alavés [Women] | 2:0 | ||||
| 27. Round | 16/04/2022 | UDG Tenerife Sur [Women] | - | SD Eibar [Women] | 3:2 | |
|||
| 28. Round | 01/05/2022 | SD Eibar [Women] | - | Villarreal CF [Women] | 1:1 | |
|||
| 29. Round | 08/05/2022 | Atlético Madrid [Women] | - | SD Eibar [Women] | 3:1 | ||||
| 30. Round | 15/05/2022 | SD Eibar [Women] | - | Valencia CF [Women] | 5:1 |
USA