| 1. Round | 07/08/2005 | Quilmes | - | Newell's Old Boys | 1:1 |  |
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| 2. Round | 13/08/2005 | Newell's Old Boys | - | Tiro Federal de Rosario | 2:1 | ||||
| 3. Round | 21/08/2005 | River Plate | - | Newell's Old Boys | 2:1 | ||||
| 7. Round | 18/09/2005 | Newell's Old Boys | - | Arsenal de Sarandí | 1:3 | ||||
| 8. Round | 24/09/2005 | Vélez Sarsfield | - | Newell's Old Boys | 1:0 |  |
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| 11. Round | 16/10/2005 | Newell's Old Boys | - | Olimpo de Bahía Blanca | 0:1 | ||||
| 12. Round | 29/10/2005 | Boca Juniors | - | Newell's Old Boys | 2:1 | ||||
| 13. Round | 06/11/2005 | Newell's Old Boys | - | Rosario Central | 2:1 | ||||
| 14. Round | 13/11/2005 | Lanús | - | Newell's Old Boys | 1:1 | ||||
| 15. Round | 17/11/2005 | Newell's Old Boys | - | Instituto de Córdoba | 5:0 | ||||
| 16. Round | 22/11/2005 | San Lorenzo | - | Newell's Old Boys | 4:2 | ||||
| 17. Round | 27/11/2005 | Newell's Old Boys | - | Argentinos Juniors | 3:0 |  |
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| 18. Round | 11/12/2005 | Gimnasia de La Plata | - | Newell's Old Boys | 0:0 | ||||
| 19. Round | 14/12/2005 | Newell's Old Boys | - | Racing Club | 0:1 |
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