| 1. Round | 24/09/1967 | Sampdoria | - | Bologna FC | 1:2 | ||||
| 2. Round | 01/10/1967 | AS Varese 1910 | - | Sampdoria | 1:0 | ||||
| 3. Round | 08/10/1967 | Sampdoria | - | AC Mantova | 3:0 | ||||
| 4. Round | 15/10/1967 | Torino FC | - | Sampdoria | 4:2 | ||||
| 5. Round | 22/10/1967 | Sampdoria | - | AS Roma | 1:1 | ||||
| 6. Round | 29/10/1967 | Brescia Calcio | - | Sampdoria | 1:2 | ||||
| 7. Round | 05/11/1967 | Sampdoria | - | SSC Napoli | 1:1 | ||||
| 8. Round | 12/11/1967 | AC Milan | - | Sampdoria | 2:0 | ||||
| 14. Round | 07/01/1968 | Sampdoria | - | Juventus | 1:1 | ||||
| 15. Round | 14/01/1968 | Atalanta | - | Sampdoria | 1:0 | ||||
| 23. Round | 10/03/1968 | Sampdoria | - | AC Milan | 0:3 | ||||
| 25. Round | 24/03/1968 | Sampdoria | - | SPAL Ferrara | 1:0 | ||||
| 27. Round | 14/04/1968 | Sampdoria | - | Inter | 2:2 | ||||
| 28. Round | 28/04/1968 | Sampdoria | - | SS L.R. Vicenza | 1:0 | ||||
| 29. Round | 05/05/1968 | Juventus | - | Sampdoria | 3:1 | ||||
| 30. Round | 12/05/1968 | Sampdoria | - | Atalanta | 0:0 |
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