| 12. Round | 25/10/2020 | FK Rostov | - | FK Khimki | 0:2 | ||||
| 13. Round | 31/10/2020 | Spartak Moskva | - | FK Rostov | 0:1 | ||||
| 14. Round | 08/11/2020 | CSKA Moskva | - | FK Rostov | 2:0 | ||||
| 15. Round | 22/11/2020 | Rubin Kazan | - | FK Rostov | 0:2 | ||||
| 16. Round | 28/11/2020 | FK Rostov | - | Dinamo Moskva | 4:1 | ||||
| 17. Round | 06/12/2020 | FK Rostov | - | FK Ufa | 0:1 | ||||
| 18. Round | 13/12/2020 | Akhmat Grozny | - | FK Rostov | 0:1 | ||||
| 19. Round | 17/12/2020 | FK Rostov | - | CSKA Moskva | 1:3 | ||||
| 20. Round | 27/02/2021 | Zenit St. Petersburg | - | FK Rostov | 2:2 |  |
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| 21. Round | 06/03/2021 | FK Rostov | - | FK Sochi | 0:0 | ||||
| 22. Round | 12/03/2021 | FK Khimki | - | FK Rostov | 1:0 | |
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| 23. Round | 17/03/2021 | Rotor Volgograd | - | FK Rostov | 0:4 |  |
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| 24. Round | 04/04/2021 | FK Rostov | - | Spartak Moskva | 2:3 | ||||
| 25. Round | 10/04/2021 | FK Rostov | - | Rubin Kazan | 0:1 | ||||
| 26. Round | 17/04/2021 | Lokomotiv Moskva | - | FK Rostov | 4:1 | ||||
| 27. Round | 25/04/2021 | FK Rostov | - | Arsenal Tula | 1:0 | ||||
| 28. Round | 02/05/2021 | FK Rostov | - | FK Tambov | 2:0 | ||||
| 29. Round | 10/05/2021 | FK Ural | - | FK Rostov | 1:0 | ||||
| 30. Round | 16/05/2021 | FK Rostov | - | FK Krasnodar | 1:3 |
Sweden