| 1. Round | 11/09/2021 | Parma Calcio 1913 [Youth] | - | US Alessandria 1912 [Youth] | 6:1 |  |
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| 3. Round | 25/09/2021 | US Cremonese [Youth] | - | US Alessandria 1912 [Youth] | 5:3 | ||||
| 6. Round | 23/10/2021 | US Alessandria 1912 [Youth] | - | Como 1907 [Youth] | 1:1 | ||||
| 7. Round | 30/10/2021 | AS Cittadella [Youth] | - | US Alessandria 1912 [Youth] | 1:0 | ||||
| 8. Round | 06/11/2021 | US Alessandria 1912 [Youth] | - | Venezia FC [Youth] | 1:1 | |
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| 14. Round | 29/01/2022 | US Alessandria 1912 [Youth] | - | Parma Calcio 1913 [Youth] | 1:4 | ||||
| 17. Round | 19/02/2022 | Brescia Calcio [Youth] | - | US Alessandria 1912 [Youth] | 3:2 | |
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| 18. Round | 26/02/2022 | US Alessandria 1912 [Youth] | - | L.R. Vicenza [Youth] | 0:1 | ||||
| 19. Round | 07/03/2022 | Como 1907 [Youth] | - | US Alessandria 1912 [Youth] | 4:4 | ||||
| 21. Round | 19/03/2022 | Venezia FC [Youth] | - | US Alessandria 1912 [Youth] | 5:1 |
Italy