| 1. Round | 28/08/2022 | Sassuolo Calcio [Women] | - | UC Sampdoria [Women] | 1:2 | ||||
| 2. Round | 11/09/2022 | UC Sampdoria [Women] | - | Pomigliano CF [Women] | 2:1 | ||||
| 3. Round | 18/09/2022 | FC Como Women [Women] | - | UC Sampdoria [Women] | 0:1 | ||||
| 4. Round | 25/09/2022 | UC Sampdoria [Women] | - | Inter [Women] | 0:2 | ||||
| 5. Round | 01/10/2022 | AC Milan [Women] | - | UC Sampdoria [Women] | 2:1 |  |
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| 6. Round | 16/10/2022 | UC Sampdoria [Women] | - | Juventus [Women] | 0:4 | ||||
| 7. Round | 23/10/2022 | ACF Fiorentina [Women] | - | UC Sampdoria [Women] | 2:1 | ||||
| 8. Round | 30/10/2022 | UC Sampdoria [Women] | - | Parma Calcio 1913 [Women] | 0:0 |  |
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| 12. Round | 11/12/2022 | UC Sampdoria [Women] | - | FC Como Women [Women] | 0:1 |
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