| 2. Round | 20/08/2021 | RB Leipzig | - | VfB Stuttgart | 4:0 | ||||
| 18. Round | 08/01/2022 | SpVgg Greuther Fürth | - | VfB Stuttgart | 0:0 | ||||
| 19. Round | 15/01/2022 | VfB Stuttgart | - | RB Leipzig | 0:2 |  |
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| 20. Round | 22/01/2022 | SC Freiburg | - | VfB Stuttgart | 2:0 | ||||
| 21. Round | 05/02/2022 | VfB Stuttgart | - | Eintracht Frankfurt | 2:3 |  |
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| 24. Round | 25/02/2022 | 1899 Hoffenheim | - | VfB Stuttgart | 2:1 | ||||
| 25. Round | 05/03/2022 | VfB Stuttgart | - | Bor. Mönchengladbach | 3:2 | |
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| 26. Round | 12/03/2022 | 1. FC Union Berlin | - | VfB Stuttgart | 1:1 | |
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| 27. Round | 19/03/2022 | VfB Stuttgart | - | FC Augsburg | 3:2 | ||||
| 28. Round | 02/04/2022 | Arminia Bielefeld | - | VfB Stuttgart | 1:1 | |
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| 30. Round | 16/04/2022 | 1. FSV Mainz 05 | - | VfB Stuttgart | 0:0 | ||||
| 31. Round | 24/04/2022 | Hertha BSC | - | VfB Stuttgart | 2:0 | ||||
| 32. Round | 30/04/2022 | VfB Stuttgart | - | VfL Wolfsburg | 1:1 | ||||
| 33. Round | 08/05/2022 | Bayern München | - | VfB Stuttgart | 2:2 | |
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| 34. Round | 14/05/2022 | VfB Stuttgart | - | 1. FC Köln | 2:1 | |
Austria