| 10. Round | 29/09/2021 | Derby County | - | Reading FC | 1:0 | ||||
| 11. Round | 02/10/2021 | Cardiff City | - | Reading FC | 0:1 | ||||
| 12. Round | 16/10/2021 | Reading FC | - | Barnsley FC | 1:0 | ||||
| 13. Round | 20/10/2021 | Reading FC | - | Blackpool FC | 2:3 |  |
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| 14. Round | 23/10/2021 | Blackburn Rovers | - | Reading FC | 2:0 | ||||
| 15. Round | 30/10/2021 | Reading FC | - | AFC Bournemouth | 0:2 | ||||
| 16. Round | 02/11/2021 | Millwall FC | - | Reading FC | 1:0 | ||||
| 17. Round | 06/11/2021 | Birmingham City | - | Reading FC | 1:2 | ||||
| 18. Round | 20/11/2021 | Reading FC | - | Nottingham Forest | 1:1 | |
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| 19. Round | 23/11/2021 | Reading FC | - | Sheffield United | 0:1 | ||||
| 20. Round | 27/11/2021 | Swansea City | - | Reading FC | 2:3 | ||||
| 21. Round | 04/12/2021 | Reading FC | - | Hull City | 1:1 | ||||
| 22. Round | 11/12/2021 | West Bromwich Albion | - | Reading FC | 1:0 | ||||
| 26. Round | 03/01/2022 | Reading FC | - | Derby County | 2:2 | ||||
| 25. Round | 11/01/2022 | Reading FC | - | Fulham FC | 0:7 | ||||
| 36. Round | 05/03/2022 | Reading FC | - | Millwall FC | 0:1 | ||||
| 37. Round | 12/03/2022 | Nottingham Forest | - | Reading FC | 4:0 | ||||
| 30. Round | 05/04/2022 | Reading FC | - | Stoke City | 2:1 |
England
