| 1. Round | 24/07/2022 | RSC Anderlecht | - | KV Oostende | 2:0 | ||||
| 2. Round | 30/07/2022 | Cercle Brugge | - | RSC Anderlecht | 1:0 | ||||
| 3. Round | 07/08/2022 | RSC Anderlecht | - | RFC Seraing | 3:1 | ||||
| 4. Round | 14/08/2022 | Sint-Truidense VV | - | RSC Anderlecht | 0:3 | ||||
| 6. Round | 28/08/2022 | Union Saint-Gilloise | - | RSC Anderlecht | 2:1 | ||||
| 5. Round | 01/09/2022 | RSC Anderlecht | - | KAA Gent | 0:1 | ||||
| 7. Round | 04/09/2022 | RSC Anderlecht | - | Oud-Heverlee Leuven | 2:2 | ||||
| 8. Round | 11/09/2022 | KVC Westerlo | - | RSC Anderlecht | 2:1 |  |
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| 9. Round | 18/09/2022 | RSC Anderlecht | - | KV Kortrijk | 4:1 | ||||
| 10. Round | 02/10/2022 | RSC Anderlecht | - | Sporting Charleroi | 0:1 | ||||
| 12. Round | 16/10/2022 | RSC Anderlecht | - | Club Brugge KV | 0:1 | ||||
| 13. Round | 20/10/2022 | SV Zulte Waregem | - | RSC Anderlecht | 3:2 | ||||
| 15. Round | 30/10/2022 | RSC Anderlecht | - | KAS Eupen | 4:2 | ||||
| 16. Round | 06/11/2022 | Royal Antwerp FC | - | RSC Anderlecht | 0:0 |
Italy