| 1. Round | 14/08/2021 | VfL Wolfsburg | - | VfL Bochum | 1:0 | ||||
| 3. Round | 28/08/2021 | 1. FC Köln | - | VfL Bochum | 2:1 | ||||
| 5. Round | 18/09/2021 | Bayern München | - | VfL Bochum | 7:0 | ||||
| 12. Round | 20/11/2021 | Bayer Leverkusen | - | VfL Bochum | 1:0 | ||||
| 13. Round | 27/11/2021 | VfL Bochum | - | SC Freiburg | 2:1 | ||||
| 14. Round | 04/12/2021 | FC Augsburg | - | VfL Bochum | 2:3 | ||||
| 15. Round | 11/12/2021 | VfL Bochum | - | Borussia Dortmund | 1:1 | ||||
| 16. Round | 14/12/2021 | Arminia Bielefeld | - | VfL Bochum | 2:0 | ||||
| 17. Round | 18/12/2021 | VfL Bochum | - | 1. FC Union Berlin | 0:1 |
Congo