| 2. Round | 06/10/1968 | Juventus | - | SSC Palermo | 0:0 | ||||
| 3. Round | 13/10/1968 | SSC Palermo | - | Inter | 1:1 |  |
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| 6. Round | 10/11/1968 | SSC Palermo | - | Torino FC | 1:0 |  |
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| 7. Round | 17/11/1968 | SSC Napoli | - | SSC Palermo | 1:0 | ||||
| 8. Round | 24/11/1968 | SSC Palermo | - | AS Varese 1910 | 1:1 | |
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| 9. Round | 01/12/1968 | SSC Palermo | - | Atalanta | 5:1 | ||||
| 10. Round | 08/12/1968 | Pisa SC | - | SSC Palermo | 4:1 | ||||
| 11. Round | 15/12/1968 | SSC Palermo | - | SS L.R. Vicenza | 2:1 | ||||
| 16. Round | 02/02/1969 | SSC Palermo | - | Cagliari Calcio | 0:0 | ||||
| 17. Round | 09/02/1969 | SSC Palermo | - | Juventus | 1:1 |  |
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| 18. Round | 16/02/1969 | Inter | - | SSC Palermo | 0:0 | ||||
| 19. Round | 23/02/1969 | SSC Palermo | - | Sampdoria | 1:0 | |
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| 22. Round | 16/03/1969 | SSC Palermo | - | SSC Napoli | 0:2 dec. | ||||
| 23. Round | 23/03/1969 | AS Varese 1910 | - | SSC Palermo | 0:0 | ||||
| 24. Round | 06/04/1969 | Atalanta | - | SSC Palermo | 2:2 | ||||
| 25. Round | 13/04/1969 | SSC Palermo | - | Pisa SC | 1:0 | ||||
| 29. Round | 11/05/1969 | Bologna FC | - | SSC Palermo | 2:0 | ||||
| 30. Round | 18/05/1969 | SSC Palermo | - | AC Milan | 0:0 |
Italy