| 24. Round | 06/02/2022 | Sampdoria | - | Sassuolo Calcio | 4:0 |  |
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| 25. Round | 13/02/2022 | AC Milan | - | Sampdoria | 1:0 | ||||
| 27. Round | 28/02/2022 | Atalanta | - | Sampdoria | 4:0 | ||||
| 28. Round | 05/03/2022 | Udinese Calcio | - | Sampdoria | 2:1 | ||||
| 29. Round | 12/03/2022 | Sampdoria | - | Juventus | 1:3 | ||||
| 30. Round | 20/03/2022 | Venezia FC | - | Sampdoria | 0:2 | ||||
| 31. Round | 03/04/2022 | Sampdoria | - | AS Roma | 0:1 | ||||
| 32. Round | 11/04/2022 | Bologna FC | - | Sampdoria | 2:0 | ||||
| 33. Round | 16/04/2022 | Sampdoria | - | US Salernitana 1919 | 1:2 |  |
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| 34. Round | 23/04/2022 | Hellas Verona | - | Sampdoria | 1:1 | ||||
| 35. Round | 30/04/2022 | Sampdoria | - | Genoa CFC | 1:0 |
Italy
