| 9. Round | 23/10/2021 | Manchester City U23 | - | Tottenham Hotspur U23 | 1:3 | ||||
| 10. Round | 30/10/2021 | Tottenham Hotspur U23 | - | Manchester United U23 | 1:0 |  |
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| 11. Round | 05/11/2021 | Brighton & Hove Albion U23 | - | Tottenham Hotspur U23 | 1:1 | ||||
| 12. Round | 22/11/2021 | Leicester City U23 | - | Tottenham Hotspur U23 | 1:4 | ||||
| 13. Round | 26/11/2021 | Tottenham Hotspur U23 | - | Everton FC U23 | 4:0 | ||||
| 14. Round | 04/12/2021 | Tottenham Hotspur U23 | - | Manchester City U23 | 3:0 | ||||
| 23. Round | 18/03/2022 | Tottenham Hotspur U23 | - | Leicester City U23 | 3:1 | ||||
| 25. Round | 25/04/2022 | Derby County U23 | - | Tottenham Hotspur U23 | 0:1 | ||||
| 26. Round | 02/05/2022 | Tottenham Hotspur U23 | - | Brighton & Hove Albion U23 | 0:0 | ||||
| 20. Round | 08/05/2022 | Chelsea FC U23 | - | Tottenham Hotspur U23 | 2:1 |
France
England