| 3. Round | 19/09/2021 | Bologna FC [Youth] | - | Inter [Youth] | 1:3 |  |
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| 6. Round | 24/10/2021 | Juventus [Youth] | - | Bologna FC [Youth] | 3:2 | ||||
| 8. Round | 06/11/2021 | Bologna FC [Youth] | - | Cagliari Calcio [Youth] | 2:3 | ||||
| 9. Round | 22/11/2021 | AS Roma [Youth] | - | Bologna FC [Youth] | 3:1 | ||||
| 10. Round | 27/11/2021 | Bologna FC [Youth] | - | Atalanta [Youth] | 1:3 | ||||
| 13. Round | 18/12/2021 | Torino FC [Youth] | - | Bologna FC [Youth] | 2:0 | ||||
| 26. Round | 02/04/2022 | Bologna FC [Youth] | - | AS Roma [Youth] | 3:0 | ||||
| 33. Round | 07/05/2022 | Hellas Verona [Youth] | - | Bologna FC [Youth] | 6:0 | ||||
| 34. Round | 14/05/2022 | Delfino Pescara [Youth] | - | Bologna FC [Youth] | 1:1 |
Italy