| 7. Round | 10/10/2022 | ACN Siena 1904 | - | Cesena FC | 0:0 | ||||
| 8. Round | 16/10/2022 | SEF Torres 1903 | - | ACN Siena 1904 | 2:0 | ||||
| 10. Round | 23/10/2022 | US Recanatese | - | ACN Siena 1904 | 2:1 | ||||
| 11. Round | 29/10/2022 | ACN Siena 1904 | - | San Donato Tavarnelle | 3:0 | ||||
| 13. Round | 13/11/2022 | ACN Siena 1904 | - | Lucchese | 0:1 | ||||
| 14. Round | 20/11/2022 | US Alessandria 1912 | - | ACN Siena 1904 | 0:1 | ||||
| 16. Round | 29/11/2022 | ACN Siena 1904 | - | Fermana FC | 2:3 |  |
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| 17. Round | 03/12/2022 | AS Gubbio | - | ACN Siena 1904 | 2:0 | |
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| 18. Round | 10/12/2022 | ACN Siena 1904 | - | US Fiorenzuola | 1:1 | ||||
| 19. Round | 17/12/2022 | Virtus Entella | - | ACN Siena 1904 | 1:2 |
Italy