| 1. Round | 30/08/2021 | Potenza | - | SSC Bari | 1:1 |  |
|||
| 2. Round | 05/09/2021 | SSC Bari | - | Monterosi FC | 4:0 |  |
|
||
| 3. Round | 12/09/2021 | AZ Picerno | - | SSC Bari | 0:1 | ||||
| 4. Round | 19/09/2021 | Calcio Catania | - | SSC Bari | annull. | |
|||
| 5. Round | 26/09/2021 | SSC Bari | - | Paganese Calcio | 1:1 | ||||
| 7. Round | 03/10/2021 | SSC Bari | - | SS Monopoli 1966 | 1:0 | ||||
| 8. Round | 10/10/2021 | SSC Bari | - | FC Turris | 4:2 | ||||
| 9. Round | 17/10/2021 | Campobasso | - | SSC Bari | 1:3 | ||||
| 11. Round | 24/10/2021 | Virtus Francavilla | - | SSC Bari | 3:0 | ||||
| 24. Round | 30/01/2022 | Paganese Calcio | - | SSC Bari | 1:2 | ||||
| 27. Round | 15/02/2022 | FC Turris | - | SSC Bari | 0:1 | ||||
| 22. Round | 22/02/2022 | SSC Bari | - | AZ Picerno | 1:0 | ||||
| 30. Round | 05/03/2022 | SSC Bari | - | Virtus Francavilla | 2:1 | ||||
| 31. Round | 13/03/2022 | US Catanzaro | - | SSC Bari | 1:2 | |
|||
| 33. Round | 20/03/2022 | Vibonese Calcio | - | SSC Bari | 0:1 | ||||
| 35. Round | 03/04/2022 | Latina Calcio | - | SSC Bari | 0:1 | ||||
| 36. Round | 10/04/2022 | SSC Bari | - | US Avellino | 1:0 | |
|||
| 37. Round | 16/04/2022 | Taranto FC | - | SSC Bari | 0:0 | ||||
| 38. Round | 24/04/2022 | SSC Bari | - | Palermo FC | 0:2 | |
Italy