| 2. Round | 29/08/2021 | Genoa CFC | - | SSC Napoli | 1:2 | ||||
| 3. Round | 12/09/2021 | Cagliari Calcio | - | Genoa CFC | 2:3 | ||||
| 4. Round | 18/09/2021 | Genoa CFC | - | ACF Fiorentina | 1:2 |  |
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| 5. Round | 21/09/2021 | Bologna FC | - | Genoa CFC | 2:2 | |
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| 6. Round | 25/09/2021 | Genoa CFC | - | Hellas Verona | 3:3 | |
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| 8. Round | 17/10/2021 | Genoa CFC | - | Sassuolo Calcio | 2:2 | ||||
| 9. Round | 22/10/2021 | Torino FC | - | Genoa CFC | 3:2 | ||||
| 10. Round | 26/10/2021 | Spezia Calcio | - | Genoa CFC | 1:1 | ||||
| 12. Round | 05/11/2021 | Empoli FC | - | Genoa CFC | 2:2 | ||||
| 16. Round | 05/12/2021 | Juventus | - | Genoa CFC | 2:0 |
Kosovo
