| 1. Round | 20/02/2022 | FC Machida Zelvia | - | FC Ryūkyū | 0:0 | ||||
| 2. Round | 27/02/2022 | FC Machida Zelvia | - | Iwate Grulla Morioka | 1:0 | ||||
| 3. Round | 06/03/2022 | Zweigen Kanazawa | - | FC Machida Zelvia | 1:2 | ||||
| 4. Round | 13/03/2022 | FC Machida Zelvia | - | Fagiano Okayama | 3:1 |  |
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| 5. Round | 20/03/2022 | Tokyo Verdy | - | FC Machida Zelvia | 2:1 | ||||
| 6. Round | 26/03/2022 | Vegalta Sendai | - | FC Machida Zelvia | 0:3 | |
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| 7. Round | 30/03/2022 | FC Machida Zelvia | - | RB Omiya Ardija | 3:0 | ||||
| 11. Round | 23/04/2022 | Ventforet Kofu | - | FC Machida Zelvia | 1:0 | ||||
| 24. Round | 02/07/2022 | FC Machida Zelvia | - | Vegalta Sendai | 2:3 | ||||
| 25. Round | 06/07/2022 | FC Machida Zelvia | - | Mito HollyHock | 2:3 | ||||
| 27. Round | 17/07/2022 | FC Machida Zelvia | - | V-Varen Nagasaki | 1:2 | ||||
| 28. Round | 23/07/2022 | Iwate Grulla Morioka | - | FC Machida Zelvia | 1:3 | ||||
| 32. Round | 20/08/2022 | RB Omiya Ardija | - | FC Machida Zelvia | 0:2 | ||||
| 38. Round | 25/09/2022 | Blaublitz Akita | - | FC Machida Zelvia | 2:1 | ||||
| 39. Round | 01/10/2022 | Tokushima Vortis | - | FC Machida Zelvia | 3:2 | ||||
| 40. Round | 09/10/2022 | FC Machida Zelvia | - | Tochigi SC | 0:1 |
Japan