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| 1st(1st leg) | Wigan Athletic | - | Stockport County | 3:0 | ||
| 2nd (2nd leg) | Stockport County | - | Wigan Athletic | 1:2 | ||
| 1st(1st leg): 31/08/1981 | 2nd (2nd leg): 14/09/1981 | Winner: Wigan Athletic | ||||
| 1st(1st leg) | Aldershot FC | - | Wimbledon FC | 0:0 | ||
| 2nd (2nd leg) | Wimbledon FC | - | Aldershot FC | 1:3 | ||
| 1st(1st leg): 01/09/1981 | 2nd (2nd leg): 15/09/1981 | Winner: Aldershot FC | ||||
| 1st(1st leg) | Bolton Wanderers | - | Oldham Athletic | 2:1 | ||
| 2nd (2nd leg) | Oldham Athletic | - | Bolton Wanderers | 4:2 aet | ||
| 1st(1st leg): 01/09/1981 | 2nd (2nd leg): 15/09/1981 | Winner: Oldham Athletic | ||||
| 1st(1st leg) | AFC Bournemouth | - | Fulham FC | 0:1 | ||
| 2nd (2nd leg) | Fulham FC | - | AFC Bournemouth | 2:0 | ||
| 1st(1st leg): 01/09/1981 | 2nd (2nd leg): 15/09/1981 | Winner: Fulham FC | ||||
| 1st(1st leg) | Bristol City | - | Walsall FC | 2:0 | ||
| 2nd (2nd leg) | Walsall FC | - | Bristol City | 1:0 | ||
| 1st(1st leg): 01/09/1981 | 2nd (2nd leg): 15/09/1981 | Winner: Bristol City | ||||
| 1st(1st leg) | Bury FC | - | Carlisle United | 3:3 | ||
| 2nd (2nd leg) | Carlisle United | - | Bury FC | 2:1 aet | ||
| 1st(1st leg): 01/09/1981 | 2nd (2nd leg): 15/09/1981 | Winner: Carlisle United | ||||
| 1st(1st leg) | Colchester United | - | Gillingham FC | 2:0 | ||
| 2nd (2nd leg) | Gillingham FC | - | Colchester United | 1:1 | ||
| 1st(1st leg): 01/09/1981 | 2nd (2nd leg): 15/09/1981 | Winner: Colchester United | ||||
| 1st(1st leg) | Darlington FC | - | Rotherham United | 1:3 | ||
| 2nd (2nd leg) | Rotherham United | - | Darlington FC | 2:1 | ||
| 1st(1st leg): 01/09/1981 | 2nd (2nd leg): 15/09/1981 | Winner: Rotherham United | ||||
| 1st(1st leg) | Doncaster Rovers | - | Chesterfield FC | 0:0 | ||
| 2nd (2nd leg) | Chesterfield FC | - | Doncaster Rovers | 1:1 aet | ||
| 1st(1st leg): 01/09/1981 | 2nd (2nd leg): 15/09/1981 | Winner: Doncaster Rovers | ||||
| 1st(1st leg) | Halifax Town | - | Preston North End | 1:2 | ||
| 2nd (2nd leg) | Preston North End | - | Halifax Town | 0:0 | ||
| 1st(1st leg): 01/09/1981 | 2nd (2nd leg): 15/09/1981 | Winner: Preston North End | ||||
| 1st(1st leg) | Huddersfield Town | - | Rochdale AFC | 3:1 | ||
| 2nd (2nd leg) | Rochdale AFC | - | Huddersfield Town | 2:4 | ||
| 1st(1st leg): 01/09/1981 | 2nd (2nd leg): 15/09/1981 | Winner: Huddersfield Town | ||||
| 1st(1st leg) | Leyton Orient | - | Millwall FC | 1:1 | ||
| 2nd (2nd leg) | Millwall FC | - | Leyton Orient | 3:2 | ||
| 1st(1st leg): 01/09/1981 | 2nd (2nd leg): 16/09/1981 | Winner: Millwall FC | ||||
| 1st(1st leg) | Northampton Town | - | Hartlepool United | 2:0 | ||
| 2nd (2nd leg) | Hartlepool United | - | Northampton Town | 2:1 | ||
| 1st(1st leg): 01/09/1981 | 2nd (2nd leg): 16/09/1981 | Winner: Northampton Town | ||||
| 1st(1st leg) | Scunthorpe United | - | Mansfield Town | 0:0 | ||
| 2nd (2nd leg) | Mansfield Town | - | Scunthorpe United | 2:0 | ||
| 1st(1st leg): 01/09/1981 | 2nd (2nd leg): 14/09/1981 | Winner: Mansfield Town | ||||
| 1st(1st leg) | Sheffield United | - | York City | 1:0 | ||
| 2nd (2nd leg) | York City | - | Sheffield United | 1:1 | ||
| 1st(1st leg): 01/09/1981 | 2nd (2nd leg): 15/09/1981 | Winner: Sheffield United | ||||
| 1st(1st leg) | Tranmere Rovers | - | Burnley FC | 4:2 | ||
| 2nd (2nd leg) | Burnley FC | - | Tranmere Rovers | 3:3 | ||
| 1st(1st leg): 01/09/1981 | 2nd (2nd leg): 15/09/1981 | Winner: Tranmere Rovers | ||||
| 1st(1st leg) | Wrexham AFC | - | Swindon Town | 3:2 | ||
| 2nd (2nd leg) | Swindon Town | - | Wrexham AFC | 0:2 | ||
| 1st(1st leg): 01/09/1981 | 2nd (2nd leg): 15/09/1981 | Winner: Wrexham AFC | ||||
| 1st(1st leg) | Bradford City | - | Blackpool FC | 3:1 | ||
| 2nd (2nd leg) | Blackpool FC | - | Bradford City | 0:0 | ||
| 1st(1st leg): 02/09/1981 | 2nd (2nd leg): 16/09/1981 | Winner: Bradford City | ||||
| 1st(1st leg) | Cardiff City | - | Exeter City | 2:1 | ||
| 2nd (2nd leg) | Exeter City | - | Cardiff City | 3:1 aet | ||
| 1st(1st leg): 02/09/1981 | 2nd (2nd leg): 16/09/1981 | Winner: Exeter City | ||||
| 1st(1st leg) | Crewe Alexandra | - | Bristol Rovers | 1:1 | ||
| 2nd (2nd leg) | Bristol Rovers | - | Crewe Alexandra | 1:0 aet | ||
| 1st(1st leg): 02/09/1981 | 2nd (2nd leg): 15/09/1981 | Winner: Bristol Rovers | ||||
| 1st(1st leg) | Hereford United | - | Port Vale FC | 1:1 | ||
| 2nd (2nd leg) | Port Vale FC | - | Hereford United | 2:0 | ||
| 1st(1st leg): 02/09/1981 | 2nd (2nd leg): 14/09/1981 | Winner: Port Vale FC | ||||
| 1st(1st leg) | Lincoln City | - | Hull City | 3:0 | ||
| 2nd (2nd leg) | Hull City | - | Lincoln City | 1:1 | ||
| 1st(1st leg): 02/09/1981 | 2nd (2nd leg): 15/09/1981 | Winner: Lincoln City | ||||
| 1st(1st leg) | Oxford United | - | Brentford FC | 1:0 | ||
| 2nd (2nd leg) | Brentford FC | - | Oxford United | 0:2 | ||
| 1st(1st leg): 02/09/1981 | 2nd (2nd leg): 15/09/1981 | Winner: Oxford United | ||||
| 1st(1st leg) | Peterborough United | - | Barnsley FC | 2:3 | ||
| 2nd (2nd leg) | Barnsley FC | - | Peterborough United | 6:0 | ||
| 1st(1st leg): 02/09/1981 | 2nd (2nd leg): 15/09/1981 | Winner: Barnsley FC | ||||
| 1st(1st leg) | Reading FC | - | Charlton Athletic | 2:2 | ||
| 2nd (2nd leg) | Charlton Athletic | - | Reading FC | 3:1 aet | ||
| 1st(1st leg): 02/09/1981 | 2nd (2nd leg): 15/09/1981 | Winner: Charlton Athletic | ||||
| 1st(1st leg) | Southend United | - | Portsmouth FC | 0:0 | ||
| 2nd (2nd leg) | Portsmouth FC | - | Southend United | 4:1 | ||
| 1st(1st leg): 02/09/1981 | 2nd (2nd leg): 16/09/1981 | Winner: Portsmouth FC | ||||
| 1st(1st leg) | Torquay United | - | Newport County | 2:3 | ||
| 2nd (2nd leg) | Newport County | - | Torquay United | 0:0 | ||
| 1st(1st leg): 02/09/1981 | 2nd (2nd leg): 15/09/1981 | Winner: Newport County | ||||
| 1st(1st leg) | Chester City | - | Plymouth Argyle | 1:1 | ||
| 2nd (2nd leg) | Plymouth Argyle | - | Chester City | 1:0 | ||
| 1st(1st leg): 08/09/1981 | 2nd (2nd leg): 15/09/1981 | Winner: Plymouth Argyle | ||||
