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| 03/02/2021 | 11:00 | AS Roma | - | Hellas Verona | 1:2 | |
| 11:00 | Cagliari Calcio | - | Bologna FC | 3:1 | ||
| 12:00 | Inter | - | FC Crotone | 3:0 | ||
| 12:30 | Atalanta | - | Lazio Roma | 1:3 | ||
| 13:00 | Empoli FC | - | SPAL 2013 Ferrara | 2:1 | ||
| 13:30 | Juventus | - | Sampdoria | 2:1 | ||
| 13:30 | Genoa CFC | - | Parma Calcio 1913 | 3:1 | ||
| 14:00 | ACF Fiorentina | - | AC Milan | 2:1 |
