Championship   M. W D L goals
  at home 10 7 2 1 31 : 7
  Away 10 2 4 4 14 : 20
  20 9 6 5 45 : 27
FA Cup   M. W D L goals
  at home 2 0 1 1 1 : 2
  Away 3 1 1 1 4 : 5
  Neutral Place 1 1 0 0 4 : 1
  6 2 2 2 9 : 8
overall   M. W D L goals
  at home 12 7 3 2 32 : 9
  Away 13 3 5 5 18 : 25
  Neutral Place 1 1 0 0 4 : 1
  26 11 8 7 54 : 35
Championship
1963/1964 5. Round Southampton FC - Grimsby Town 6:0
1963/1964 1. Round Grimsby Town - Southampton FC 2:2
1962/1963 9. Round Southampton FC - Grimsby Town 4:1
1962/1963 5. Round Grimsby Town - Southampton FC 4:1
1950/1951 8. Round Southampton FC - Grimsby Town 5:1
1950/1951 3. Round Grimsby Town - Southampton FC 4:2
1949/1950 5. Round Grimsby Town - Southampton FC 1:1
1949/1950 1. Round Southampton FC - Grimsby Town 1:2
1948/1949 9. Round Southampton FC - Grimsby Town 0:0
1948/1949 9. Round Grimsby Town - Southampton FC 0:1
1933/1934 9. Round Southampton FC - Grimsby Town 4:2
1933/1934 5. Round Grimsby Town - Southampton FC 3:1
1932/1933 8. Round Grimsby Town - Southampton FC 2:2
1932/1933 3. Round Southampton FC - Grimsby Town 3:0
1928/1929 9. Round Southampton FC - Grimsby Town 3:1
1928/1929 4. Round Grimsby Town - Southampton FC 2:1
1927/1928 7. Round Southampton FC - Grimsby Town 5:0
1927/1928 2. Round Grimsby Town - Southampton FC 2:2
1926/1927 9. Round Southampton FC - Grimsby Town 0:0
1926/1927 4. Round Grimsby Town - Southampton FC 0:1
FA Cup
2022/2023 Round of 16 Southampton FC - Grimsby Town 1:2 (0:1)
1977/1978 3. Round Grimsby Town - Southampton FC 1:4
1977/1978 3. Round Southampton FC - Grimsby Town 0:0
1977/1978 3. Round Grimsby Town - Southampton FC 0:0
1954/1955 2. Round Grimsby Town - Southampton FC 4:1
1920/1921 2. Round Grimsby Town - Southampton FC 1:3

For games that were decided on penalties the score after 120 minutes will be included in the ranking