FA Cup   M. W D L goals
  at home 1 1 0 0 4 : 3
  1 1 0 0 4 : 3
League Cup   M. W D L goals
  Away 1 1 0 0 6 : 0
  1 1 0 0 6 : 0
League One   M. W D L goals
  at home 2 2 0 0 6 : 3
  Away 2 1 0 1 3 : 2
  4 3 0 1 9 : 5
overall   M. W D L goals
  at home 3 3 0 0 10 : 6
  Away 3 2 0 1 9 : 2
  Neutral Place 0 0 0 0 0 : 0
  6 5 0 1 19 : 8
FA Cup
2005/2006 3. Round Southampton FC - Milton Keynes Dons 4:3 (1:0)
League Cup
2015/2016 3. Round Milton Keynes Dons - Southampton FC 0:6 (0:3)
League One
2010/2011 40. Round Southampton FC - Milton Keynes Dons 3:2 (0:1)
2010/2011 2. Round Milton Keynes Dons - Southampton FC 2:0 (0:0)
2009/2010 37. Round Milton Keynes Dons - Southampton FC 0:3 (0:0)
2009/2010 14. Round Southampton FC - Milton Keynes Dons 3:1 (0:1)

For games that were decided on penalties the score after 120 minutes will be included in the ranking