FA Cup   M. W D L goals
  at home 2 0 2 0 3 : 3
  Away 3 1 0 2 2 : 8
  5 1 2 2 5 : 11
League One   M. W D L goals
  at home 8 4 2 2 12 : 9
  Away 8 3 0 5 8 : 12
  16 7 2 7 20 : 21
League Two   M. W D L goals
  at home 3 2 0 1 2 : 1
  Away 3 2 0 1 4 : 3
  6 4 0 2 6 : 4
National League   M. W D L goals
  at home 1 1 0 0 2 : 1
  Away 1 0 1 0 1 : 1
  2 1 1 0 3 : 2
overall   M. W D L goals
  at home 14 7 4 3 19 : 14
  Away 15 6 1 8 15 : 24
  Neutral Place 0 0 0 0 0 : 0
  29 13 5 11 34 : 38
FA Cup
2021/2022 2. Round Leyton Orient - Tranmere Rovers 4:0 (2:0)
2009/2010 1. Round Leyton Orient - Tranmere Rovers 0:1 (0:0)
2009/2010 1. Round Tranmere Rovers - Leyton Orient 1:1 (0:1)
1953/1954 3. Round Leyton Orient - Tranmere Rovers 4:1
1953/1954 3. Round Tranmere Rovers - Leyton Orient 2:2
League One
2013/2014 45. Round Leyton Orient - Tranmere Rovers 2:0 (1:0)
2013/2014 12. Round Tranmere Rovers - Leyton Orient 0:4 (0:1)
2012/2013 32. Round Leyton Orient - Tranmere Rovers 2:1 (1:0)
2012/2013 1. Round Tranmere Rovers - Leyton Orient 3:1 (1:0)
2011/2012 36. Round Tranmere Rovers - Leyton Orient 2:0 (2:0)
2011/2012 2. Round Leyton Orient - Tranmere Rovers 0:1 (0:0)
2010/2011 45. Round Leyton Orient - Tranmere Rovers 0:3 (0:2)
2010/2011 20. Round Tranmere Rovers - Leyton Orient 1:2 (0:2)
2009/2010 32. Round Tranmere Rovers - Leyton Orient 2:1 (2:0)
2009/2010 17. Round Leyton Orient - Tranmere Rovers 2:1 (1:1)
2008/2009 31. Round Tranmere Rovers - Leyton Orient 0:0 (0:0)
2008/2009 11. Round Leyton Orient - Tranmere Rovers 0:1 (0:1)
2007/2008 31. Round Tranmere Rovers - Leyton Orient 1:1 (1:0)
2007/2008 25. Round Leyton Orient - Tranmere Rovers 3:0 (1:0)
2006/2007 35. Round Leyton Orient - Tranmere Rovers 3:1 (3:1)
2006/2007 6. Round Tranmere Rovers - Leyton Orient 3:0 (2:0)
League Two
2022/2023 29. Round Tranmere Rovers - Leyton Orient 1:0 (0:0)
2022/2023 7. Round Leyton Orient - Tranmere Rovers 2:0 (1:0)
2021/2022 46. Round Leyton Orient - Tranmere Rovers 0:1 (0:1)
2021/2022 22. Round Tranmere Rovers - Leyton Orient 1:0 (0:0)
2020/2021 32. Round Leyton Orient - Tranmere Rovers 1:3 (0:1)
2020/2021 7. Round Tranmere Rovers - Leyton Orient 0:1 (0:0)
National League
2017/2018 33. Round Leyton Orient - Tranmere Rovers 1:1 (0:1)
2017/2018 14. Round Tranmere Rovers - Leyton Orient 2:1 (1:1)

For games that were decided on penalties the score after 120 minutes will be included in the ranking