| 1. Round | 11/09/2021 | Ternana Calcio [Youth] | - | Pisa SC [Youth] | 1:3 |  |
|||
| 3. Round | 25/09/2021 | Cosenza Calcio [Youth] | - | Pisa SC [Youth] | 2:1 |  |
|||
| 5. Round | 16/10/2021 | Cesena FC [Youth] | - | Pisa SC [Youth] | 3:2 | ||||
| 7. Round | 31/10/2021 | Spezia Calcio [Youth] | - | Pisa SC [Youth] | 1:0 | ||||
| 8. Round | 06/11/2021 | Pisa SC [Youth] | - | Reggina 1914 [Youth] | 0:0 | ||||
| 10. Round | 27/11/2021 | Pisa SC [Youth] | - | FC Crotone [Youth] | 2:1 | ||||
| 13. Round | 18/12/2021 | Pisa SC [Youth] | - | Benevento Calcio [Youth] | 1:0 | ||||
| 14. Round | 29/01/2022 | Pisa SC [Youth] | - | Ternana Calcio [Youth] | 1:0 | ||||
| 15. Round | 05/02/2022 | Frosinone Calcio [Youth] | - | Pisa SC [Youth] | 2:5 | |
|||
| 18. Round | 26/02/2022 | Pisa SC [Youth] | - | Cesena FC [Youth] | 1:3 | ||||
| 19. Round | 05/03/2022 | US Salernitana 1919 [Youth] | - | Pisa SC [Youth] | 2:1 | ||||
| 20. Round | 12/03/2022 | Pisa SC [Youth] | - | Spezia Calcio [Youth] | 3:0 | ||||
| 23. Round | 02/04/2022 | FC Crotone [Youth] | - | Pisa SC [Youth] | 1:0 | ||||
| 25. Round | 16/04/2022 | Pisa SC [Youth] | - | Lazio Roma [Youth] | 2:1 |
Italy