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| 05/03/2022 | 09:30 | Reggina 1914 | - | Spezia Calcio | 1:0 (1:0) | |
| 10:00 | Cesena FC | - | Lazio Roma | 3:1 (2:0) | ||
| 10:30 | Ascoli Calcio | - | AC Perugia Calcio | 0:0 (0:0) | ||
| 13:00 | Ternana Calcio | - | Frosinone Calcio | 0:5 (0:0) | ||
| 13:30 | US Salernitana 1919 | - | AC Pisa | 2:1 (1:0) | ||
| 14:00 | Cosenza Calcio | - | FC Crotone | 2:2 (0:0) |
| » Tables | Home | Away | First round | Second round |
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Cesena FC | 17 | 13 | 1 | 3 | 51:28 | 23 | 40 |
| 2 |
|
Lazio Roma | 18 | 12 | 2 | 4 | 49:17 | 32 | 38 |
| 3 |
|
Frosinone Calcio | 18 | 11 | 3 | 4 | 50:29 | 21 | 36 |
| 4 |
|
Benevento Calcio | 17 | 10 | 0 | 7 | 27:27 | 0 | 30 |
| 5 |
|
Spezia Calcio | 18 | 9 | 2 | 7 | 32:26 | 6 | 29 |
| 6 |
|
AC Pisa | 17 | 9 | 1 | 7 | 30:26 | 4 | 28 |
| 7 |
|
AC Perugia Calcio | 17 | 8 | 2 | 7 | 33:28 | 5 | 26 |
| 8 |
|
Ascoli Calcio | 17 | 8 | 2 | 7 | 28:23 | 5 | 26 |
| 9 |
|
Reggina 1914 | 18 | 6 | 2 | 10 | 21:39 | -18 | 20 |
| 10 |
|
US Salernitana 1919 | 18 | 6 | 0 | 12 | 29:39 | -10 | 18 |
| 11 |
|
Cosenza Calcio | 17 | 5 | 3 | 9 | 28:38 | -10 | 18 |
| 12 |
|
FC Crotone | 18 | 3 | 3 | 12 | 25:53 | -28 | 12 |
| 13 |
|
Ternana Calcio | 18 | 2 | 3 | 13 | 16:46 | -30 | 9 |
| Promotion | |
| Playoffs |
