| 23. Round | 23/01/2022 | Kasımpaşa SK | - | Kayserispor | 3:1 |  |
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| 24. Round | 04/02/2022 | Kayserispor | - | Hatayspor | 4:3 | ||||
| 25. Round | 12/02/2022 | Galatasaray | - | Kayserispor | 1:1 | ||||
| 26. Round | 19/02/2022 | Kayserispor | - | Giresunspor | 2:1 | |
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| 28. Round | 07/03/2022 | Kayserispor | - | Alanyaspor | 1:2 |  |
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| 30. Round | 18/03/2022 | Fatih Karagümrük | - | Kayserispor | 3:0 | |
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| 31. Round | 02/04/2022 | Kayserispor | - | Fenerbahçe | 0:4 | ||||
| 33. Round | 15/04/2022 | Kayserispor | - | Çaykur Rizespor | 1:1 | ||||
| 34. Round | 24/04/2022 | Antalyaspor | - | Kayserispor | 1:1 | ||||
| 35. Round | 01/05/2022 | Kayserispor | - | Beşiktaş | 2:3 |
Italy
