6. Round | 14/08/2022 | Guaraní | - | Club Nacional | 1:1 | ||||
7. Round | 21/08/2022 | Cerro Porteño | - | Guaraní | 1:1 | ||||
8. Round | 27/08/2022 | Libertad | - | Guaraní | 2:2 | ||||
14. Round | 03/10/2022 | Guaraní | - | Resistencia SC | 0:1 | ||||
15. Round | 07/10/2022 | 12 de Octubre de Itauguá | - | Guaraní | 0:1 | ||||
16. Round | 13/10/2022 | Guaraní | - | Sol de América | 4:1 | ||||
18. Round | 23/10/2022 | Guaraní | - | Cerro Porteño | 1:2 | ||||
19. Round | 27/10/2022 | Guaraní | - | Libertad | 1:2 | ||||
20. Round | 30/10/2022 | Guaireña FC | - | Guaraní | 1:0 | ||||
21. Round | 06/11/2022 | Guaraní | - | Tacuary | 2:1 | ||||
22. Round | 13/11/2022 | Sportivo Ameliano | - | Guaraní | 4:2 |