| 8. Round | 06/11/2021 | Pisa SC [Youth] | - | Reggina 1914 [Youth] | 0:0 | ||||
| 10. Round | 27/11/2021 | Ascoli Calcio [Youth] | - | Reggina 1914 [Youth] | 2:0 | ||||
| 12. Round | 11/12/2021 | AC Perugia Calcio [Youth] | - | Reggina 1914 [Youth] | 2:0 | ||||
| 13. Round | 19/12/2021 | Reggina 1914 [Youth] | - | Cesena FC [Youth] | 2:1 | ||||
| 16. Round | 12/02/2022 | Reggina 1914 [Youth] | - | Ternana Calcio [Youth] | 3:1 | ||||
| 17. Round | 19/02/2022 | US Salernitana 1919 [Youth] | - | Reggina 1914 [Youth] | 1:2 | ||||
| 18. Round | 26/02/2022 | Lazio Roma [Youth] | - | Reggina 1914 [Youth] | 0:1 | ||||
| 19. Round | 05/03/2022 | Reggina 1914 [Youth] | - | Spezia Calcio [Youth] | 1:0 | ||||
| 21. Round | 19/03/2022 | Reggina 1914 [Youth] | - | Pisa SC [Youth] | 0:2 | ||||
| 20. Round | 29/03/2022 | FC Crotone [Youth] | - | Reggina 1914 [Youth] | 2:2 | ||||
| 23. Round | 02/04/2022 | Reggina 1914 [Youth] | - | Ascoli Calcio [Youth] | 1:0 |  |
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