| Group F | 20/10/2020 | Lazio Roma | - | Borussia Dortmund | 3:1 |  |
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| Group F | 28/10/2020 | Club Brugge KV | - | Lazio Roma | 1:1 |  |
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| Group F | 04/11/2020 | Zenit St. Petersburg | - | Lazio Roma | 1:1 | |
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| Group F | 24/11/2020 | Lazio Roma | - | Zenit St. Petersburg | 3:1 | ||||
| Group F | 02/12/2020 | Borussia Dortmund | - | Lazio Roma | 1:1 | ||||
| Group F | 08/12/2020 | Lazio Roma | - | Club Brugge KV | 2:2 | ||||
| Round of 16 | 23/02/2021 | Lazio Roma | - | Bayern München | 1:4 | ||||
| Round of 16 | 17/03/2021 | Bayern München | - | Lazio Roma | 2:1 |
France