| 1. Round | 04/06/2022 | Banfield | - | Newell's Old Boys | 1:2 | ||||
| 3. Round | 15/06/2022 | Banfield | - | Central Córdoba SdE | 2:1 | ||||
| 4. Round | 19/06/2022 | Tigre | - | Banfield | 0:1 | ||||
| 5. Round | 24/06/2022 | Banfield | - | Barracas Central | 1:1 | ||||
| 6. Round | 02/07/2022 | Boca Juniors | - | Banfield | 0:3 | ||||
| 7. Round | 09/07/2022 | Banfield | - | Unión de Santa Fe | 2:3 | ||||
| 8. Round | 17/07/2022 | Banfield | - | San Lorenzo | 1:1 | ||||
| 12. Round | 06/08/2022 | Banfield | - | Patronato de Paraná | 0:0 | ||||
| 13. Round | 12/08/2022 | Platense | - | Banfield | 3:1 | ||||
| 14. Round | 19/08/2022 | Banfield | - | Racing Club | 0:2 | ||||
| 15. Round | 22/08/2022 | Rosario Central | - | Banfield | 0:1 | ||||
| 16. Round | 27/08/2022 | Banfield | - | Defensa y Justicia | 1:2 | ||||
| 18. Round | 11/09/2022 | Banfield | - | Colón de Santa Fe | 2:1 |  |
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| 19. Round | 14/09/2022 | River Plate | - | Banfield | 1:2 | ||||
| 20. Round | 18/09/2022 | Banfield | - | Lanús | 1:2 |  |
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| 21. Round | 23/09/2022 | Huracán | - | Banfield | 3:1 | ||||
| 23. Round | 05/10/2022 | Vélez Sarsfield | - | Banfield | 1:0 | ||||
| 25. Round | 12/10/2022 | Aldosivi | - | Banfield | 0:1 | ||||
| 26. Round | 16/10/2022 | Independiente | - | Banfield | 1:0 | ||||
| 27. Round | 23/10/2022 | Banfield | - | Sarmiento de Junín | 0:0 |
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