| 1. Round | 20/07/2021 | Godoy Cruz | - | Rosario Central | 2:1 | ||||
| 2. Round | 25/07/2021 | Defensa y Justicia | - | Godoy Cruz | 1:2 | ||||
| 3. Round | 28/07/2021 | Godoy Cruz | - | Atlético Tucumán | 1:2 |  |
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| 4. Round | 31/07/2021 | Colón de Santa Fe | - | Godoy Cruz | 1:0 | ||||
| 5. Round | 08/08/2021 | Godoy Cruz | - | River Plate | 2:1 | ||||
| 7. Round | 21/08/2021 | Godoy Cruz | - | Huracán | 1:1 | ||||
| 8. Round | 26/08/2021 | Godoy Cruz | - | Unión de Santa Fe | 1:2 | ||||
| 9. Round | 29/08/2021 | Vélez Sarsfield | - | Godoy Cruz | 3:0 | ||||
| 15. Round | 11/10/2021 | Arsenal de Sarandí | - | Godoy Cruz | 0:0 | |
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| 19. Round | 31/10/2021 | San Lorenzo | - | Godoy Cruz | 1:0 | ||||
| 20. Round | 06/11/2021 | Godoy Cruz | - | Talleres de Córdoba | 0:2 | ||||
| 21. Round | 20/11/2021 | Argentinos Juniors | - | Godoy Cruz | 0:0 | |
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| 23. Round | 27/11/2021 | Patronato de Paraná | - | Godoy Cruz | 0:3 |
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