| Group K | 14/09/2017 | Vitesse | - | Lazio Roma | 2:3 |  |
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| Group K | 28/09/2017 | Lazio Roma | - | SV Zulte Waregem | 2:0 | ||||
| Group K | 02/11/2017 | Lazio Roma | - | OGC Nice | 1:0 | ||||
| Round of 32 | 22/02/2018 | Lazio Roma | - | FCSB | 5:1 | ||||
| Round of 16 | 08/03/2018 | Lazio Roma | - | Dinamo Kiev | 2:2 | ||||
| Round of 16 | 15/03/2018 | Dinamo Kiev | - | Lazio Roma | 0:2 | ||||
| Quarter-finals | 05/04/2018 | Lazio Roma | - | RB Salzburg | 4:2 | |
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| Quarter-finals | 12/04/2018 | RB Salzburg | - | Lazio Roma | 4:1 |
Italy