| 13. Round | 19/12/2021 | Reggina 1914 [Youth] | - | Cesena FC [Youth] | 2:1 | ||||
| 14. Round | 29/01/2022 | Reggina 1914 [Youth] | - | Frosinone Calcio [Youth] | 2:3 | ||||
| 15. Round | 05/02/2022 | Cosenza Calcio [Youth] | - | Reggina 1914 [Youth] | 3:1 | ||||
| 16. Round | 12/02/2022 | Reggina 1914 [Youth] | - | Ternana Calcio [Youth] | 3:1 |  |
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| 17. Round | 19/02/2022 | US Salernitana 1919 [Youth] | - | Reggina 1914 [Youth] | 1:2 | ||||
| 19. Round | 05/03/2022 | Reggina 1914 [Youth] | - | Spezia Calcio [Youth] | 1:0 | ||||
| 21. Round | 19/03/2022 | Reggina 1914 [Youth] | - | Pisa SC [Youth] | 0:2 | ||||
| 20. Round | 29/03/2022 | FC Crotone [Youth] | - | Reggina 1914 [Youth] | 2:2 | ||||
| 23. Round | 02/04/2022 | Reggina 1914 [Youth] | - | Ascoli Calcio [Youth] | 1:0 | ||||
| 24. Round | 09/04/2022 | Benevento Calcio [Youth] | - | Reggina 1914 [Youth] | 4:4 | ||||
| 25. Round | 16/04/2022 | Reggina 1914 [Youth] | - | AC Perugia Calcio [Youth] | 0:3 |
Italy