| 2. Round | 18/09/2021 | Pisa SC [Youth] | - | Frosinone Calcio [Youth] | 3:1 | ||||
| 3. Round | 25/09/2021 | Cosenza Calcio [Youth] | - | Pisa SC [Youth] | 2:1 | ||||
| 5. Round | 16/10/2021 | Cesena FC [Youth] | - | Pisa SC [Youth] | 3:2 | ||||
| 6. Round | 23/10/2021 | Pisa SC [Youth] | - | US Salernitana 1919 [Youth] | 4:2 | ||||
| 7. Round | 31/10/2021 | Spezia Calcio [Youth] | - | Pisa SC [Youth] | 1:0 | ||||
| 8. Round | 06/11/2021 | Pisa SC [Youth] | - | Reggina 1914 [Youth] | 0:0 | ||||
| 10. Round | 27/11/2021 | Pisa SC [Youth] | - | FC Crotone [Youth] | 2:1 | ||||
| 13. Round | 18/12/2021 | Pisa SC [Youth] | - | Benevento Calcio [Youth] | 1:0 | ||||
| 11. Round | 22/12/2021 | Pisa SC [Youth] | - | AC Perugia Calcio [Youth] | 3:1 | ||||
| 19. Round | 05/03/2022 | US Salernitana 1919 [Youth] | - | Pisa SC [Youth] | 2:1 | ||||
| 21. Round | 19/03/2022 | Reggina 1914 [Youth] | - | Pisa SC [Youth] | 0:2 |
Italy